High-Dose IV Vitamin C & G6PD Testing: What You Need to Know

Vitamin C is widely known for immune support, but when delivered intravenously at therapeutic doses, it plays a much broader role in inflammation regulation, immune modulation, oxidative stress reduction, and cellular support.

As with any advanced IV therapy, appropriate screening and dosing are essential—this is where G6PD testing comes in.

Why IV Vitamin C Is Different From Oral Vitamin C

When vitamin C is taken orally, absorption is limited by the gastrointestinal tract. Even very large oral doses result in relatively modest blood levels due to tight intestinal regulation.

IV vitamin C bypasses digestion entirely, allowing plasma concentrations to reach levels that are 10–100 times higher than oral supplementation. These higher concentrations are what allow vitamin C to support immune resilience, inflammation balance, and oxidative stress regulation.

Benefits of High-Dose Vitamin C Infusions

1. Immune System Support

Vitamin C plays a key role in immune defense. At higher intravenous doses, it may:

• Support immune cell function
• Assist the body during periods of immune stress
• Help regulate excessive inflammatory immune responses

Many patients choose high-dose vitamin C as part of an immune-supportive or recovery-focused wellness plan.

2. Reduction of Oxidative Stress

Oxidative stress occurs when free radicals exceed the body’s antioxidant capacity. High-dose IV vitamin C functions as a potent antioxidant, helping neutralize free radicals and support cellular protection.

This can be especially beneficial for individuals experiencing:

• Chronic inflammation
• Environmental toxin exposure
• High physical or emotional stress

3. Inflammation Modulation

Vitamin C influences multiple inflammatory pathways in the body. Therapeutic IV dosing is often incorporated into wellness strategies aimed at supporting inflammation balance and tissue recovery.

4. Collagen, Tissue, and Vascular Support

Vitamin C is essential for collagen synthesis, which supports:

• Skin integrity and wound healing
• Blood vessel health
• Joint and connective tissue function

This makes high-dose vitamin C a common component of recovery-oriented and longevity-focused wellness plans.

5. Cellular Energy & Recovery Support

Vitamin C supports mitochondrial health and adrenal function. Many patients report improved resilience, enhanced recovery after illness or exertion, and improved overall vitality when IV vitamin C is used appropriately as part of a comprehensive plan.

Individual responses vary based on overall health, lifestyle, and medical history.

High-Dose Vitamin C Dosing at Summit Wellness

At Summit Wellness, high-dose vitamin C infusions are clinically guided and personalized rather than one-size-fits-all.

We offer therapeutic IV vitamin C doses ranging from 10 grams up to 25 grams, depending on individual needs, goals, and clinical appropriateness. These doses allow plasma vitamin C levels not attainable through oral supplementation alone.

For doses of 25 grams and above, a G6PD level is required prior to infusion to ensure patient safety.

Why We Check a G6PD Level Before Higher-Dose Vitamin C

Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that protects red blood cells from oxidative damage.

In individuals with G6PD deficiency, exposure to high oxidative stress—including very high-dose vitamin C—can overwhelm red blood cells and increase the risk of hemolysis (red blood cell breakdown).

While G6PD deficiency is relatively uncommon, it often goes undiagnosed without testing.

Our Safety-First Protocol

• Vitamin C doses of 25g and higher require documented G6PD testing
• Testing can be drawn in-house at Summit Wellness
• Patients may also provide recent G6PD results from an outside laboratory
• All infusions are administered under medical supervision with individualized dosing

This protocol ensures high-dose vitamin C therapy is delivered safely, responsibly, and effectively.

Who May Be a Good Candidate for High-Dose Vitamin C?

High-dose vitamin C may be considered for individuals seeking additional support for:

• Immune resilience
• Inflammation balance
• Recovery from physical, metabolic, or environmental stress
• Cellular and antioxidant support

A consultation is always required to determine appropriateness, dosing, and any necessary lab work.

Personalized IV Therapy at Summit Wellness

At Summit Wellness, IV therapy is never about trends—it’s about precision, personalization, and clinical integrity.

High-dose vitamin C is offered as part of a customized wellness plan, guided by lab data, medical evaluation, and individual goals.

📍 Orange Beach, Alabama
📞 Schedule a consultation to learn if high-dose vitamin C IV therapy is right for you.